X-ray crystallography covers a certain part of the pharmacological relevant drug target space. Cryo-EM is a complementary method that gives access to difficult-to-crystallize protein classes, including multi-protein complexes, antibodies and transmembrane proteins.
Proteros´s proven track record in industrial protein construct design, expression and purification for challenging biological targets positions the company to immediately provide cryo-EM suitable protein for both EM feasibility analysis and for Gene-to-Structure projects.
Proteros` cryo-EM workflow starts with protein production and moves to EM feasibility analysis, which is also known as negative staining EM. This work is followed by cryo-EM condition optimization, leading to low resolution or high resolution cryo-EM structure and structure analysis.
Cryo-EM service complements our protein crystallography work by providing our customers with structural information of their drug target that are otherwise not accessible by X-ray crystallography.
Proteros`cryo-EM services span the entire cryo-EM workflow. Based on our proven track record in industrial protein construct design, expression and purification delivered by our protein sciences staff of over 40 scientists, Proteros is ideally suited to meet cryo-EM protein demands.
EM feasibility analysis is applied to evaluate cryo-EM protein suitability and cryo-EM condition optimization to obtain the ideal grid quality for measurement. Proteros will cooperate with external partners (Technical University Munich) to access high-end microscopes detection suitable for all cryo-EM measurement steps.
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