Proteros biostructures GmbH now offers cryo-EM drug discovery services aimed at deciphering complex and challenging structural biology targets, which are not accessible by traditional X-ray crystallography. Proteros´ expertise in X-ray crystallography and protein construct design is well known in the scientific drug discovery community. The company adds cryo-EM to its drug discovery service offerings to meet the growing industry demand to resolve structures of complex drug targets, such as large protein complexes, antibodies and membrane proteins.
Proteros’ proven track record in industrial protein construct design, expression and purification expertise for challenging biological targets positions the company to immediately provide cryo-EM suitable protein for EM feasibility analysis and corresponding Gene-to-Structure projects. Proteros will collaborate with external partner (Technical University Munich) to access high-end microscopes detection suitable for all cryo-EM measurement steps.
The Proteros cryo-EM service offering includes protein production and protein-EM feasibility analysis (negative staining), cryo-EM condition optimization as well as low and high resolution cryo-EM structure determination and analysis with or without ligands. Proteros customers will also benefit from the company’s two decades experience of structure analysis.