At Proteros, we have assembled a world class team of 60 scientists.
So far, more than 250 peer reviewed publications of Proteros´ key scientists have been published.

Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site. Chen H., Tucker J., Wang X., Gavin P., Phillips C., Augustin M., Schreiner P., Steinbach S., Preston M., Ogg D. Acta Crystallogr D Struct Biol. 2016 May 1;72(Pt 5):682-93. doi: 10.1107/S2059798316004502. Epub 2016 Apr 26. Abstract
On-rate based optimization of structure–kinetic relationship – surfing the kinetic map Schoop, A. , Dey, F. (2015) Drug Discovery Today: Technologies, Vol. 17, Oct. 2015, Page 9-15 Abstract
Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization. Okamoto K, Ikemori-Kawada M, Jestel A, von König K, Funahashi Y, Matsushima T, Tsuruoka A, Inoue A, Matsui J. ACS Med Chem Lett. 2014 Nov 17;6(1):89-94. doi: 10.1021/ml500394m. eCollection 2015 Jan 8. Abstract
Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody. Eylenstein R., Weingärtner D., Härte S., Stromer R., Böttcher J., Augustin M., Ostendorf R., Steidl S. MAbs. 2016;8(1):176-86. doi: 10.1080/19420862.2015.1099774. Epub 2015 Sep 25. Abstract
IR laser-induced protein crystal transformation Kiefersauer, R. et al. (2014) Acta Cryst. Section D (2014) D70 Abstract
Structural analysis of the human fibroblast growth factor receptor 4 kinase. Leica E., Lammens A., Huber R., Augustin M. J Mol Biol. 2014 Nov 11;426(22):3744-56. doi: 10.1016/j.jmb.2014.09.004. Epub 2014 Sep 16. Abstract
Structural and functional analysis of the natural JNK1 inhibitor quercetagetin Baek, S. et al. (2013) J Mol Biol. 425, 411-23 Abstract
The E. coli effector protein NleF is a Caspase inhibitor Blasche, S. et al. (2013) PLoS One. 8, 58937 Abstract
Discovery and optimization of a novel series of potent mutant B-Raf V600E selective kinase inhibitors Vasbinder, M.M., et al. (2013) J Med Chem. 56, 1996-2015 Abstract
Structure-Kinetic-Relationship study of CDK8/CycC specific compounds Schneider, E.V. et al.(2013) Proc Natl Acad Sci USA. 110, 8081-6 Abstract
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability Lauffer, B.E.L. et al.(2013) J Biol Chem. 288, 26926-43 Abstract
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin k inhibitors Crawford, J.J. et al.(2012) J Med Chem. 55, 8827-37 Abstract
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition Dossetter, A.G. et al.(2012) Bioorg Med Chem Lett. 22, 5563-8 Abstract
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis Dossetter, A.G. et al. (2012) J Med Chem. 55, 6363-74 Abstract
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors Fradera, X. et al.(2012) Acta Crystallogr Sect F Struct Biol Cryst Commun. 68, 404-8 Abstract
HTS reporter displacement assay for fragment screening and fragment evolution toward leads with optimized binding kinetics, binding selectivity, and thermodynamic signature Neumann, L. et al.(2011) Methods Enzymol. 493, 299-320 Abstract
The structure of CDK8/CycC implicates specificity in the CDK/Cyclin family and reveals interaction with a deep pocket binder Schneider, E.V. et al.(2011) J Mol Biol. 412, 251-266 Abstract
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers Gerritz, S.W. et al. (2011) Proc Natl Acad Sci USA. 108, 15366-71 Abstract
Key factors for successful generation of protein-fragment structures requirement on protein, crystals, and technology Böttcher, J. et al.(2011) Methods Enzymol. 493, 61-89 Abstract
The ‘retro-design’ concept for novel kinase inhibitors Müller, G. et al.(2010) IDrugs. 13, 457-66 Abstract
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions Buttar, D. et al.(2010) Bioorg Med Chem. 18, 7486-7496 Abstract
The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis Wang, J. et al. (2010) Biochemistry. 49, 7972-4 Abstract
Fragment-based discovery of BACE1 inhibitors using functional assays Godemann, R. et al.(2009) Biochemistry. 48, 10743-51 Abstract
Fragment-based lead generation: identification of seed fragments by a highly efficient fragment screening technology Neumann, L. et al.(2009) J Comput Aided Mol Des. 23, 501-11 Abstract
Dipeptidyl nitrile inhibitors of Cathepsin L Asaad, N. et al. (2009) Bioorg Med Chem Lett. 19, 4280-4283 Abstract
Design of selective Cathepsin inhibitors Bethel, P.A. et al.(2009) Bioorg Med Chem Lett. 19, 4622-5 Abstract
Structural and functional studies of the yeast class II Hda1 histone deacetylase complex Lee, J.H. et al.(2009) J Mol Biol. 391, 744-57 Abstract
Phosphorylation of the human full-length protein kinase C-iota Macek, B. et al.(2008) J Proteome Res. 7, 2928-35 Abstract
Macrocyclic statine-based inhibitors of BACE-1 Barazza, A. et al.(2007) Chembiochem. 8, 2078-91 Abstract
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif Messerschmidt, A. et al.(2005) J Mol Biol. 352, 918-931 Abstract
Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor Roehrig S. er al.(2005) J Med Chem. 48, 5900-8 Abstract